The symptoms of Cystic Fibrosis occur because a mutation in the gene that codes

Question

The symptoms of Cystic Fibrosis occur because a mutation in the gene that codes for a transport protein in lung tissue responsible for transporting chloride ions from the interior lung surface into the cell. If this protein is faulty, chloride ions are not moved from one side of the cell membrane to the other side, and thus the ions build up in the fluid immediately outside of the cell. Why do cells need transport proteins to move chloride ions? Explain how chloride ions are transported into a cell via transport proteins.

Explanation / Answer

1.1 The protein function as a channel across the membrane of cells that produce mucus,sweat ,saliva tears, and digestive enzymes.The channel transports the negatively charged ions ( chloride ions) in to out of cells.The transport of chloride ions helps the control movement of water tissues which is ncessary for the production of thin,freely flowing mucus.Mucus is a slippery substance that lubricates and protects the lining of the airways, digestive system , reproductive system and other organs and tissues.

1.2 the membrane protien transport the negatively charged from inside the the cell to the outside ( into extracellular space).the ions flow from high concenration to low concenration(outside the cell),this means negative charge built on the outside of the cell, positively charged sodium ions follow the chloride ions by passive diffusion.This ions are scereted in to mucus in the extra cellular space..this leads to higher concentrations of salts outside the cell,which cause water to leave the cell followed by the higher concenration of saltswhich makes the mucus thinner. when Cystic fibrosis gene is mutated this function is impaired and ions cannot be transported across the memebrane. This cause higher electrolyte concentration inside the cell and water stays there..this causes mucus to get thicker. which can block fine channels of lungs and also bacteria can grow in the thicker mucus which can cause pneumonia.

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