Given the two pedigrees (for an X-linked recessive trait) in kangaroos, determin

Question

Given the two pedigrees (for an X-linked recessive trait) in kangaroos, determine the genotype of the parents for this disease gene? Determine whether the paternal or the maternal X is inactivated in female kangaroos? Justify your conclusion. Assume that the OCA_2 gene is required for eye color in the iris in humans. A famous movie star Charon Stoner had unusual rainbow colored eyes. Your friend Ro receives a letter in 2010 asking for a donation to support the cloning of Charon's mutant OCA2 gene. Charon disappeared in 1994 while monitoring lizards. Ro promptly sends the money. Do you think Ro made a wise decision? (Explain fully why you reach this conclusion) b) A year later, you watch a documentary, where a woman named Sharon Rock claims to have received Charon's kidney during a kidney transplant in 1992. Sharon allows you to obtain cells (only a few cells) from this kidney. The sequence of the wild type gene is known. You isolate genomic DNA from the donated kidney cells, PCR up Charon's mutant OCA2 gene (using sequence homology to the wild type gene) and clone it so that you will be able to express the gene) gene in the eye. Is this the best way to isolate Charon's mutant OCA2 gene? If not what is the best way? You introduce the mutant clone into Ro's iris cells but find that while Ro's iris makes the mutant protein it does not produce rainbow colored eyes. Sharon is not a fraud. Based on your knowledge of human genetics how would you most easily explain this result?

Explanation / Answer

I DONT THIINK ONLY SENDING MONEY IS A WISE DECISION.

it should be donated. So that study of that particular subject can be done.

this will be helpful not only for that particular person or for particular organism , it will be helpfull for all.

futhermore it may leads to new discoveries that may help the mankind in future.

THATSWHY STUDY FOR THAT PARTICULAR SUBJECT IS MUST.

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