(Biochemistry) These questions really confuse me and I never get them 100% right
ID: 912427 • Letter: #
Question
(Biochemistry)
These questions really confuse me and I never get them 100% right! Help!
Not yet answered Points out of 2.00 Flag question Which of the following is NOT correct about the signal transduction pathway for insulin mediated regulation? Select one or more: The phosphorylated other proteins (e.g., IRS-1) move to the nucleus to directly activate the transcription of genes in response to insulin. Conformational changes in the alpha subunits induces the beta subunits to undergo autophosphorylation by activating the kinase activity and a third protein. Two insulin molecules bind to its receptor to two alpha subunits The phosphorylated other proteins (e.g., IRS-1) activate other kinases which convert the signaling molecule PIP2 to PIP3. The phosphorylated beta domains lead to the phosphorylation of other proteins (e.g., IRS-1) Question 4 Not yet answered Points out of 2.00 Y Rag question What steps in the cascade involved in converting insulin binding to changes in metabolic enzymes (e.g., glycogen synthesis) are correct? Select one or more: This results in the phosphorylation of numerous other kinases, including glycogen synthase kinase (GSK). GS is activated and glycogen synthesis is accelerated. IRS-1 phosphorylation leads to P13K binding GSK phosphorylation leads to its activation, and glycogen synthase (GS) is phosphorylated. P13K converts PIP2 to PIP3Explanation / Answer
3). The folowing statement is not correct about he signal transduction pathway for insulin mediated regulation:
a. The phosphorelated other proteins (e.g, IRS-1) move to the nucleus to directly activate the transcription of genes in response to insulin.
A phospholipase enzyme cleave the phospholipid which anchors Tubby to the cell membrane, thereby releasing the Tubby and allowing it to move to the nucleus and activate its target genes.
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