For a given disorder you genotype 10,000 cases and 10,000 controls for a SNP wit

Question

For a given disorder you genotype 10,000 cases and 10,000 controls for a SNP with alleles G and A. You observe 1100 cases and 900 controls have the A allele (all others have G). Create a 2 times 2 table (Table 1) with columns "cases" and "controls" and rows "A allele" and "G allele". Populate the fields with the corresponding values. Calculate the odds ratio for getting the disease if you have the A allele. _____ This SNP is located between two genes. Give two possible explanations for why an allele at this SNP is associated with the disease. Explanation #1: Explanation #2:

Explanation / Answer

Answer:

Based on the given information:

1) The contingency 2 x 2 table with column cases and controls and rows Alleles A and G is as below

2) Odds ratio for getting the disease if we have A allele is:

Odds ratio = odds of disease due to Allele A / odds of disease due to Allele G = (1100/900)/(8100/9100) = 1.25. Odds ratio of more than 1 implies that A allele is associated with the disease.

3) This SNP is located between two genes. Give two possible explanations for why an allele at this SNP is associated with the disease.

An allele at this SNP is associated with the disease because:

Cases Control A alleles 1100 900 G alleles 8900 9100

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