Low concentrations of warfarin near the detection limit gave the following dimen

Question

Low concentrations of warfarin near the detection limit gave the following dimensionless instrument readings: 196.3, 159.5, 153.3, 165.3, 210.3, 151.1, 214.1, 192.7, 125.7, and 196.5. Ten blanks had a mean reading of 55.3. The slope of the calibration curve is 1.10 × 109 M–1. Estimate the signal and concentration detection limits and the lower limit of quantitation for warfarin.

Map a sapling learning Low concentrations of warfarin near the detection limit gave the following dimensionless instrument readings: 196.3, 159.5,153.3, 165.3, 210.3, 151.1, 214.1, 192.7, 125.7, and 196.5. Ten blanks had a mean reading of 55.3. The slope of the calibration curve is 1.10 x10° M-1. Estimate the signal and concentration detection limits and the lower limit of quantitation for warfarin. Number Signal Detection Limit: Number Concentration Detection Limit: Number Lower Limit of Quantitation:

Explanation / Answer

For the above question, you need the following values:

Standard deviations of concentration reading and standard deviations of blank

Once you have these values, the following values can be obtained by the formulas given below:

Signal detection limit = mean (blank) + SD(blank)

Concentration detection limit= SDL + SD (low concentration sample)

Lower limit of quantitation: lowest concentration at which the analyte can not only be reliably detected but at which some predefined goalsfor bias and imprecision are met.

Lower limit of quantitation: It may be equal to limit of detection or may not be.

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