under certain circumstances, axons in the peripheral nervous system can regenera

Question

under certain circumstances, axons in the peripheral nervous system can regenerate after sustaining damage. Why is axonal regeneration in the central nervous system much less likely? under certain circumstances, axons in the peripheral nervous system can regenerate after sustaining damage. Why is axonal regeneration in the central nervous system much less likely? under certain circumstances, axons in the peripheral nervous system can regenerate after sustaining damage. Why is axonal regeneration in the central nervous system much less likely?

Explanation / Answer

The axons present in the peripheral nerves are surrounded by myelin and it is covered with endoneurium. This loose connective tissue creates a directional tube to the target organ. If the endoneurium is intact after axonal injury, the axonal "bud" is able to grow within the endoneurial tube to its former destination. In the central nervous system, endoneurial tissue is absent. Axonal regeneration is therefore limited in this part of the nervous system.

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