Mutations in the gene encoding Breast Cancer Type 1 Susceptibility Protein (know

Question

Mutations in the gene encoding Breast Cancer Type 1 Susceptibility Protein (known as BRCA1) are thought to be responsible for 45% of inherited breast cancers. The BRCA1 protein is composed of 1863 amino acids. The amino acid composition of BRCA1 is the following:

Ala 84  
Arg 76  
Asn 121  
Asp 85  
Cys 44  
Gln 97  
Glu 198     
Gly 87  
His 49  
Ile 77  
Leu 156  
Lys 137  
Met 30     
Phe 49  
Pro 96  
Ser 224     
Thr 111     
Trp 10  
Tyr 31  
Val 101

Based on this information, decide which statement is TRUE (choose all correct answers, more than one answer may be correct). Assume that at pH 7, the electric charge of the histidine side chain is 0.

A. At pH 7, BRCA1 will bind to a column of beads containing positively charged groups

B. At pH 7, BRCA1 will bind to a column of beads containing negatively charged groups

C. At pH 7, BRCA1 will not bind to a column of beads containing positively charged groups

D. At pH 7, BRCA1 will not bind to a column of beads containing negatively charged groups

Explanation / Answer

The net charge on BRCA1 is negative so

(A) At pH 7, BRCA1 will bind to a column of beads containing positively charged groups

(D) At pH 7, BRCA1 will not bind to a column of beads containing negatively charged groups

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