are numerous examples of microorganisms displaying each of the four major resist
ID: 88615 • Letter: A
Question
are numerous examples of microorganisms displaying each of the four major resistance mechanisms. In this activity, you are asked to identify the mechanism that each each item into the appropriate bin. Many strains of Neisseria are resistant to penicillin because of the production of beta Resistance to tetracycline may result from modified pore proteins in the outer membrane that form a porin too small for the tetracycline to pass through Pseudomonas aeruginosa has membrane pumps that export a number of different from its cells. MRSA (methicillin-resistant Staphylococcus aurums) is resistant to all beta-tactam drugs because of a mutation in its penicillin-binding protein (PBP)Explanation / Answer
1. Enzymatic deactivation of the antibiotic- (1) many strain of neisseria gonorrhoeae are resistant to penicillin because of production of b lactarnases.
2. Prevention of penetration within target site- (1) resistance of tetracycline may results from modified pore protein in the outer membrane that form a porin too small for the tetracycline to pass through.
3. Alteration of drug target site- (1) MRSA is resistant to all b tactum drugs because of its penicillin binding protein.
(2) resistance to clindamycin develops when mutations in bacteria alter the ribosomal binding site to which clindamycin will normally bind.
4. Rapid efflux of antibiotics- (1) Pseudomonas euroginosa has membrane pumps which exports a number of different antibiotics from its cells
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