2.PS1. 8 4. Blood plasma viscosity = 0.02 poise (dyne s cm - 2 ) The “fractional
ID: 884333 • Letter: 2
Question
2.PS1.
8
4. Blood plasma viscosity = 0.02 poise (dyne s cm
-
2
)
The “fractional pore area” is the total area of the pores divided by the total area of the membrane. (A dyne
is a g cm s
-
2
).
B.
Calculate the glomerular filtration rate (GFR) assuming a total area for both kidneys of 1.5
m
2
and a driving force) P = 20 mm Hg. The GFR is the total volume of ultrafiltrate produced
per min. Its units should be in cm
3
min
-
1
.
22.
Plasma contains
a variety of proteins that exert osmotic pressure. A list of these, their molecular
weights and approximate protein concentrations are given below:
Protein
Average Molecular
Weight
Concentration in Plasma
Albumin
69,000
4.2 g/dL
Fibrinogen
330,000
0.3
g/dL
Immunoglobin G
150,000
0.8 g/dL
Immunoglobin M
750,000
0.3 g/dL
"
2
globulins
100,000
0.7 g/dL
"
1
globulins
50,000
0.5 g/dL
$ globulins
100,000
0.8 g/dL
From this data calculate the approximate osmotic pressure in plasma that is due just to
plasma proteins at
body temperature.
Explanation / Answer
Osmotic pressure = pi * C * R * T
= 3.14 * 1.52 * 0.082 * (37.5 + 273)
= 121.52 atm
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