The citric acid cycle is the very heart of metabolism. Several catabolic pathway

Question

The citric acid cycle is the very heart of metabolism. Several catabolic pathways feed into it -- including, of course, glycolysis.

Which of the following is true about the CAC?

A. Two products from glycolysis (pyruvate and NADH) feed directly into the CAC.

B. In the first step of the CAC, HSCoA is released from one of the reactants.

C. There are 4 oxidation steps in the CAC, all of which use NAD(+) as oxidizing agent.

D. All 8 steps of the CAC have dGo' values that are negative.

E. All of the above are true.

Explanation / Answer

A. False: The pyruvate is first converted to acetyl Co-A

B.In the first step of the CAC, HSCoA is released from one of the reactants: True

C. False : Four of the eight steps in this process are oxidations, in which the energy of oxidation is conserved, with high efficiency, in the formation of reduced cofactors (NADH and FADH2).

D. All 8 steps of the CAC have dGo' values that are negative: False only three steps have delta G negative.

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