Amyloid fibrils are associated with many fatal degenerative diseases of humans a

Question

Amyloid fibrils are associated with many fatal degenerative diseases of humans and livestock. Livestock diseases such as scrapie in sheep and bovine spongiform encephalitis (BSE, or mad cow disease) have major negative impacts on agriculture. Human diseases characterized by amyloid fibrils include Alzheimer's disease and Creutzfeldt-Jakob disease. T

Choose the true statements about amyloid fibrils. (More than 1.)

Amyloid fibrils have a high amount of -helical structure.

Proteins that convert to an amyloid structure form soluble fibrils.

Some amyloid fibrils are formed from proteolytic fragments that self-assemble into extended -sheet structures.

Proteins that form amyloid fibrils are normally soluble.

Nucleation of amyloid structure may be triggered when two -sheet regions from two partially folded proteins associate.

Explanation / Answer

True Statements:

C. Some amyloid fibrils are formed from proteolytic fragments that self-assemble into extended -sheet structures.

D. Proteins that form amyloid fibrils are normally soluble.

E. Nucleation of amyloid structure may be triggered when two -sheet regions from two partially folded proteins associate.

False Statements:

A. Amyloid fibrils have a high amount of -helical structure (Because it is in beta helical structure).

B. Proteins that convert to an amyloid structure form soluble fibrils.

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