The size of the Saccharomyces cerevisiae (yeast, the one you use to bake bread)

Question

The size of the Saccharomyces cerevisiae (yeast, the one you use to bake bread) genome is about 1.5 * 10^7 base pairs. Yeast, which uses 400 replication origins to replicate its 17 chromosomes, takes 30 minutes to complete S phase. Assume all replicons (A replicon is a region of DNA that replicates from a single origin of replication (bidirectionally)) are the same size, initiate replication at the same time during the cell cycle and are replicated at the same rate. How many base pairs will be replicated every minute per replicon? A 500,000 bp/min/replicon B 1250 bp/min/replicon C 400 bp/min/replicon D 3750 bp/min/replicon E 1825 bp/min/replicon

Explanation / Answer

Number of base pairs = 1.5 * 107

Number of replicons = 400

Number of bases per replicons = 1.5 * 107/400 = 3.75 * 104 = 37500

Time taken to replicate = 30 min

rate of bp synthesised per min per replicon = 37500/30 = 1250

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