Biology 1610 Intro Genetics Help Close Extra Credit 12 Chapter 12 Question 12 Ca

Question

Biology 1610 Intro Genetics Help Close Extra Credit 12 Chapter 12 Question 12 Case Study previous l 2 of 6 l next Chapter 12 Question 12 Case Study What are the molecular targets of anticancer drugs? The bark of the Pacific yew tree (Taxus brevifolia) was the original source of one of the most effective drugs for treating tumors of the breast, lung, and other sites. Taxol, a chemical extracted from this bark, kills actively replicating cells by inhibiting the depolymerization of microtubules. Why are microtubules good targets for killing cancerous cells? Part A When actively growing cells are treated with Taxol, they often are unable to complete the cell cycle. Based on what you have learned about cell-cycle checkpoints, which checkpoint likely causes these cells to arrest? Explain your reasoning G1 checkpoint. If the growth of the cell was blocked, or if DNA was physically damaged and cannot be repaired, then the cell would arrest in G1 phase The first M phase checkpoint. If the sister chromatids all kinetochores are not attached properly to the spindle apparatus, then the sister chromatids do not split and the cells would arrest in M phase Go checkpoint. If DNA is damaged or if chromosomes are not replicated correctly, the inhibitory phosphate on MPF's Cdk subunit won't removed. As a result, MPF is not turned on, and cells remain in G2 phase. The second M phase checkpoint. If microtubule depolymerization were inhibited, the chromosomes would not completely separate in anaphase, and the cells would arrest in M phase Submit My Answers Give Up Provide Feedback Continue

Explanation / Answer

Taxol block the depolymerization of the microtubule that occurs during the anaphase of M phase in which the chromosomes are pulled towards opposite pole. Due to lack of pulling, separation of the chromosomes is not possible. Hence the cells will be arrested at M phase checkpoint

Related Questions

Navigate

• Browse (All)
• Browse B
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.