The GTPase Dynamin is involved in which step of vesicular trafficking? A) bindin

Question

The GTPase Dynamin is involved in which step of vesicular trafficking? A) binding of cargo molecules to cargo receptors B) assembly of the clathrin coat C) pinching off of the vesicle from the membrane D) transport of vesicles along microtubules Which of the following events does not occur in the rough endoplasmic reticulum? A) Cleavage of the signal peptide by the signal peptidase B) Binding of chaperone proteins to misfolded or partially folded proteins C) Transfer of a pre-formed oligosaccharide to a new polypeptide by oligosaccharyl transfera D) Degradation of misfolded proteins by the ubiquitin proteasome system E) Formation of vesicles destined for the Golgi apparatus Which of the following elements is not required for transport of a soluble protein into the lumen A) ER signal sequence b) protein translator C) signal recognition particle receptor D) stop transfer sequence Your friend works in a biotechnology company and has discovered a drug that blocks the ab exchange GDP for GTP. What is the most likely effect of this drug on nuclear transport? A) Nuclear transport receptors would be unable to bind cargo. B) Nuclear transport receptors would be unable to enter the nucleus. C) Nuclear transport receptors would be unable to release their cargo in the nucleus. D) Nuclear transport receptors would interact irreversibly with the nuclear pore fibrils. The packing of proteins into secretory vesicles occurs in discrete steps. Which one describes the correct order of the events listed in I-V below? I. The GTPase dynamin pinches off the vesicle from membrane of origin II. Clathrin binds to adaptin III. Clathrin coat falls off IV. Cargo receptor binds cargo A) II, I, III IV B) I, II, IV, III C) IV, I, III, II D) IV, I, III, II Signal sequence that direct proteins to the endoplasmic reticulum are ___ ? A) Added to proteins through post translational modification B) Encoded in the amino acid sequence C) Added to a protein by a protein translator D) Not removed and remain attached to the protein Cholesterol uptake by cells occurs though which of the following endocytic pathway A) Phagocytosis B) Pinocytosis C) Receptor mediated endocytosis D) All of the above Which of the following statements about microtubule growth in cells is false? A) Microtubule growth is dependent on the y-tubulin ring complex B) GTP bound a and b tubulin dimers add on to the minus of microtubules C) Microtubules undergo dynamin instability D) Microtubules are stabilized by being captured at the cells cortex

Explanation / Answer

Ans 1. (C)

Ans 2. (D)

Ans 3. (D) For translocation of transmembrane proteins it requires “start-transfer” or “stop-transfer” signals, but itis not required in soluble protein transport

Ans 4. (A)

Ans 5. (A)

Ans 6. (B)

Ans 7. (C)

Ans 8. (D)

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