Some intermediate molecular weight (IMW) molecules may be responsible for toxic

Question

Some intermediate molecular weight (IMW) molecules may be responsible for toxic effects associated with kidney dialysis. However, these molecules bind to plasma proteins, principally albumin, reducing their transport across the dialysis membrane. A novel membrane has been developed that produces high clearance at high flow rates or dials sate. Use the data given below to compute the IMW extraction fraction (Extraction fraction E=K/QB) for countercurrent exchange with and without protein in solution and compare with the result for urea. As noted, many of these intermediate-molecular-weight molecules bind to albumin that is too big to move across the membrane. Thus, the total concentration of these molecules (CiBT) equals the sum of the free molecule (CiBr) and the albumin-bound molecule (CiBboand). The loss of IMW molecules from the blood is based on the total amount of IMW molecules. Assuming that the number of binding sites for the IMW molecules is large, the bound concentration is proportional to the free concentration, Since only the free molecule can move across the membrane, membrane transport depends only on the free molecule Use these results to show that an equation similar to can be derived for except that QB is replaced with QB (1+KA). Assuming that QB is replaced with QB (1+KA), determine the value of KA for the intermediate molecular weight protein.

Explanation / Answer

a)So IMW extraction fraction is E= K/QB   where sub B represents blood flow rate.

IMW without protein, E= KforIMW/ QB = 136/208= .654

IMW with protein= 24/208= .11

IMW urea= 200/208= .962

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