Question 36 of 37 Incorrect pling Give the pKa values for the protonatable group

Question

Question 36 of 37 Incorrect pling Give the pKa values for the protonatable groups of proline, and then calculate its pl. (Answers within t 0.3 pH units will be accepted). Number C OH pKa 2.34 (COOH) Number pKa 9.69 H2N Number (NH2 The pl of proline 6.015 Incorrect. The secondary amine structure, 5-membered ring, and steric constraints combine to cause the a imino nitrogen of proline to have a considerably higher pKa than the a-amino groups of other amino acids. The value you entered is too low. Map

Explanation / Answer

pKa of Proline (a-amino) = 10.6

pKa of proline (COOH) =2.0

so pI = 10.6 + 2.0 / 2 = 6.3

so pI of Proline = 6.3

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