Draw a hypothetical metabolic pathway composed of five substrates, five enzymes,

Question

Draw a hypothetical metabolic pathway composed of five substrates, five enzymes, and a product called Biological Sciazine. Number the substrates 1-5, and label the enzymes A-E, in order. (For instance, enzyme A catalyzes the reaction between substrates 1 and 2)


a. Suppose a mutation made the gene for enzyme C nonfunctional. What molecule would accumulate in the affected cells?

b. Suppose some individuals can survive if given substrate 5 in the diet, but they die if given substrates 1, 2, 3, and 4. Which enzyme pathway is affected by this mutation?

Explanation / Answer

The pathway can be drawn in the following manner:      A         B           C          D           E 1----->2------>3------->4------->5------> biological Sciazine. a. If enzyme C was non-functional due to a mutation. The molecule or substrate which would accumulate would be 3. b. If some individuals can survive if given substrate 5 but cannot survive if given substrates1,2,3 and 4 it indicates that all the enzymes A,B,C,D are mutated and non-functional.

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