1 A 30 yr old woman is admitted to the hospital. she has truncal obesity, buffal
ID: 85504 • Letter: 1
Question
1
A 30 yr old woman is admitted to the hospital. she has truncal obesity, buffalo humpback, moon face, purple striae, hypertension, hyperglycemia, increased facial hair, acne, and amenorrhea. the physician orders endocrine testing. Results are:
Urine free cortisol- increased; Serum cortisol (8am)- increased; Plasma ACTH- decreased;;
Dexamethasone Supression test:
Overnight low dose- no supression of serum cortisol
High Dose- no supression of serum cortisol
In your opinion what is the probable diagnosis of the woman's condition?
2
In a patient, the concentration of vancomycin is 20 ug/mL at 1200. At 1600, the vancomycin concentration is 12 ug/mL. What is the elimination constant for this patient? What is the vancomycin's half-life?
Explanation / Answer
Answer:
1) Based on the given information the symptoms of the women are:
The most probable diagnosis based on the given symptoms and tests is Adrenocortical carcinoma which is a rare endocrine malignancy caused as a result of cancerous growth in the adrenal cortex. The characteristic symptoms are presence of a noticable lump in the abdomen, buffalo hump on the back side, appearance of increased body hairs (virilization), rounded moon face.
In this disease, hormone levels ACTH will be low and Aldesterone will be high.
2) Elimination rate constant can be determined as below:
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