Some forms of cleft palate are caused by recessive alleles of a gene on the X ch

Question

Some forms of cleft palate are caused by recessive alleles of a gene on the X chromosome. In an Icelandic population, 3.6 times 10^-3 of the females have this form of cleft palate. What proportion of the males would you expect to be affected, assuming Hardy-Weinberg equilibrium? 1.3 times 10^-5 3.6 times 10^-3 1.6 times 10^-3 6.0 times 10^-2 0 In a tropical human population in Hardy-Weinberg equilibrium for an autosomal locus determining presence/absence of pigment in the skin, the frequency of albinism (aa) is 1 in 10,000. The frequency of heterozygotes is approximately: 1 in 25. 1 in 50. 1 in 75 1 in 100.

Explanation / Answer

Please find the answers below:

Part 1: Choice 3

Explanation: According to the information, the allele resides on the X-chromosome of the females at a frequency of 3.6*10-3. Thus, for a male being affected by this disease which is recessively inherited in Hardy Weinberg equilibrium, the calculations can be found as below:

Here, p2 = 3.6*10-3, thus, p=0.6* 10-2.

Since p+q=1, we can have q=1-p or q = 1-0.6 = 0.4*10-2.

Thus, q2 - 1.6*10-3

Part 2: Chioce 2

Explanation: According to the information, the frequency of recessive allele is 1 in 10000 or 10-4. Thus, the value of p will be square root of 10-4 i.e. 10-2. Thus, the value of q will be 1-0.01 or 0.09. Thus, the value of heterozygotes will be 2pq = 2*0.1*0.9 = 0.18 or nearly 1/50.

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