What is the significance of balanced levels of dNTPs during DNA synthesis? A sin
ID: 83923 • Letter: W
Question
What is the significance of balanced levels of dNTPs during DNA synthesis?
A single dNTP at high levels is more likely to be misincorporated, while a single dNTP at very low levels is more likely to be replaced by another during DNA synthesis.
An excess of one of the dNTPs is likely to inhibit 3' -> 5' exonuclease activity.
An excess of one of the dNTPs is likely to inhibit DNA repair mechanisms.
An excess of one of the dNTPs is likely to inhibit synthesis of RNA primers.
A single dNTP at high levels is more likely to be misincorporated, while a single dNTP at very low levels is more likely to be replaced by another during DNA synthesis.
Explanation / Answer
The answer will be the first option. A single dNTP at high level is more likely to be misincorporated, while a single dNTP at very low level more likely to be replaced by another during DNA synthesis. The dNTP are incorporated into DNA by a kind of trial and error method the right dNTP base always fits in the pocket of DNA POLYMERASE. so if some kind of dNTP are in high concentrations then that particular dNTP has a high probability to bind in catabolic site. And also can't fit in that site and cleaved out.so the process will hamper.
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