According to the BEIR VII Report, the total risk for all classes of genetic dise

Question

According to the BEIR VII Report, the total risk for all classes of genetic diseases is about 3,000 to 4, 700 cases per million first generation progeny per gray low-LET exposure. Using this information and the combined data for 30-year-old males and females from Problem 1, calculate: The number of persons with fatal cancer (SC & L) in a population of 10,000 per of exposure The number of new genetic mutations in 10,000 first generation progeny per of exposure Complete the following table: TABLE 12-6 Committee's Preferred Estimates of Lifetime Attributable Risk (LAR) of Solid Cancer Incidence and Mortality^a (with 95% subjective CIs)^b "These were obtained as the sum of site-specific LAR estimates. The site-specific estimates were obtained as a weighted average (on a logarithmic scale) of estimates based on relative and absolute risk transport. For sites other than lung, breast, and thyroid, relative risk transport was given a weight of 0.7 and absolute risk transport was given a weight of 0.3. These weights were reversed for lung cancer. Models for breast and thyroid cancer were based on data that included Caucasian subjects. The resulting linear estimates were reduced by a DDREF of 1.5. Including uncertainty from sampling variability, transport, and DDREF. The uncertainty evaluation was based on evaluation of estimates based on analyses of LSS cohort data on all solid cancers analyzed as a single category as described in Annex 12C.

Explanation / Answer

answer 1. number of persons with fatal cancer in a population of 10000 per rem of exposure can be calculated as follows:

(320 + 490) / 2 = 405

answer 2. number of new genetic mutations in 10000 persons will be

(1330 + 2530) / 2 = 1930

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.