Question 6 A) Woud N-1,5-dimethylhexylformamide be an effective alternative for

Question

Question 6

A) Woud N-1,5-dimethylhexylformamide be an effective alternative for the treatment of methanol and ethylene glycol poisoning, assuming that it is non-toxic itself (and as an alternative to getting the patient drunk)? Would N-1,5-dimethylhexylformamide be effective even if the concentrations of methanol or ethylene glycol were very high? (Hint: Compare the values of KI and KI' whichever is appropriate and Km).

B) The compound 4-methyl pyrazol eis curently being used as a treatment for methanol poisoning. How owuld the effectiveness of 4-methyl pyrazole compare with the effectiveness of a formamide treatment?

Explanation / Answer

a) Yes, N-1,5-dimethylhexylformamide would be an effective alternative for the treatment of methanol and ethylene glycol poisoning, as it is non-toxic itself.

Also, the action of N-1,5-dimethylhexylformamide is similar to alcohol dehydrogenase present in our liver.

It acts as uncompetitive inhibitor for treatment of methanol and ethylene glycol poisoning.

Also

KM of ADH1 without inhibitor = 0.3069

KM of ADH1 with inhibitor = 0.1157 , so it is effective inhibitor to treate the alcohol poisoning.

b) If we compare the effectiveness of 4-methyl pyrzole as compared to formamide, 4-methyl pyrzole becomes ineffective high substrate concentration while formamides being having action of binding with E-NADH complex in place of free enzyme or enzyme substrate complex they act as non competitive. They are analog to alehyde.

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