In the first step of glycolysis, the following two reactions are coupled: Reacti

Question

In the first step of glycolysis, the following two reactions are coupled: Reaction 1: glucose + P, rightarrow glucose - 6 - phosphate + H20 A(7 = + 13.8 kJ/mol Reaction2: ATP + H20 rightarrow ADP + P, deltaG = - 30.5 kJ/mol Answer the following four questions about the first step of glycolysis: Is Reaction 1 spontaneous or nonspontaneous? Write the net chemical equation. Use the same spelling as is shown in the reactions above. Calculate the overall AG for the coupled reaction. Is the first step in glycolysis spontaneous (favorable)?

Explanation / Answer

1) nonspontaneous because deltaG is positive

2) glucose + ATP --> glucose-6-phosphate + ADP

3) -16.7 kJ/mol

4) yes, because deltaG is negative

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