The anticancer drug Gleevec, which is used to treat a subset of leukemia patient

Question

The anticancer drug Gleevec, which is used to treat a subset of leukemia patients, blocks the activity of which enzyme? A) Acetyl-Transferases B) Methyl-transferases C) Kinase D) Dephosphatases E) None of the above RNA polymerase III synthesizes A) tRNA B) mRNA C) rRNA D) cDNA miRNA mediates mRNA degradation by the help of which protein/enzyme below A) Histones B) Restriction enzymes C) RISC complex D) Pseudogenes would be transcribed to compensate for the decreased protein in the cell. Degradation of cyclins is controlled by which modification? A) Phosphorylation B) Ubiquitination C) dephosphorylation D) Transcription E) All of the above Muscle cells & nerve cells in one species of animal owe their differences in structure/function to A) Having different genetic composition B) Having different chromosomal structure. C) Using different genetic elements/loci D) Differential gene expression. E) Having unique combination of ribosomes. If you were to observe the activity of methylated DNA, you would expect it to be? A) Provide a non-replicating locus of Genetic material B) Unwinding in preparation for protein synthesis. C) Have turned off or slowed down the process of transcription. D) Be very active in translation. E) protein synthesis by allowing repressors bind to it.

Explanation / Answer

Please find the answers below:

Part 5: Choice C (Gleevec, chemically known as imtinib actually, is a specifit tyrosine kinase inhibitor by nature and generally used in chemotherapy of lukemia)

Part 6: Choice C (RNA polymerase III is directly involved in synthesis of both mRNA and tRNA but synthesis of ribosomal small unit 5S rRNA is highly specific to it)

Part 7: Choice C (miRNA or siRNA are small interfering RNA or micro-RNAs which silence the target site by synthesis of a RNA-induced silencing comlex. This complex comprises of many enzymes and stereospecific oreintation of RNA to help the miRNA silence the target.)

Part 8: Choice E (Cylcins are regulators of cell cycle division controls and get activated/deactivated by presence/absence of other factors along with phosphorylation/dephosphorylation or ubiquitination in some cases)

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