Integrating its genome into that of the host basal cells (analogous to phage lys

Question

Integrating its genome into that of the host basal cells (analogous to phage lysogeny. presented in Section 12.3). The integrated genome can transform host cells into cancer cells through increased expression of viral oncogenes (genes that cause cancer). The main oncogenes of HPV are proteins E6 and E7 (see Figure 12.196), which inhibit the expression of host tumor suppressor genes such as p53 and pRB. Replication of HVV is activated when a) keratinocytes differentiate? b) The DNA is unwanted C) Infracting basal cells d) Integrating into the host genome.

Explanation / Answer

Answer: (a) Keratinocytes differentiate

This is because keratinocytes are the host for HPV and so when they start to differentiate it makes the HPV to replicate.

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