Which of the following statements regarding the influenza virus is FALS? a. The

Question

Which of the following statements regarding the influenza virus is FALS? a. The genome of influenza is very tiny to allow the generation of as many virions as possible. b. The influenza genome maximizes gene reassortment. c. The genome of influenza .s well designed for evasion of the immune system. A small subset of the human population not express the and CCR5 receptors. To what virus are these individuals naturally ? a) HIV? b) HPV c) In Fluenza d) Hepatitis Which oF the following viruses is capable of causing a syncytium? a) Hepatitis b) in Fluenza c) HPV? d) HIV

Explanation / Answer

1. a. People who do not express the CD4 and CCR5 receptors are naturally immune to HIV. HIV requires both CD4 and CCR5 receptors to infect a cell. If the coreceptor CCR5 is missing, HIV cannot penetrate a CD4 cell. People who are defective in both copies of the CCR5 co-receptor are immune to HIV. People who have one good copy of the coreceptor gene and one defective copy contract HIV more slowly. Certain strains of HIV can use another coreceptor called CXCR4 for entry into cells.

2. d. HIV can cause the formation of a syncitium, upon infection of cells. A syncitium is a giant multinuclear cell formed by the fusion of several mononuclear cells. Viral fusion proteins used by the virus to enter a cell cause the hosts cell membrane to fuse with adjacent neighbouring cells.

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