Under what circumstances does the bifunctional protein phosphofructokinase-2/fru

Question

Under what circumstances does the bifunctional protein phosphofructokinase-2/fructose 2, 6-bisphosphatase (PFK-2/FBPase-2) become phosphorylated, and what are the consequences of its phosphorylation to the glycolytic and gluconeogenic pathways? Low Glucose favors PKA activity; pPFK-2 makes F26BP which favors gluconeogenesis Low Glucose favors PKA activity; pPFK-2 makes F26BP which favors glycolysis High Glucose favors PKA activity; FBPase-2 depletes F26BP which favors gluconeogenesis High Glucose favors PKA activity; FBPase-2 depletes F26BP which favors glycolysis None of the above

Explanation / Answer

The correct answer of this question is option (A). Low glucose favors PKA activity; pPFK-2 makes F26BP which favors glucogenesis

Glucagon was stimulated by the low blood sugar level and it further stimulate the Cyclic adenosine monophosphate (cAMP) synthesis which causing phosphorylate Phosphofructokinase 2 (PFK-2) by protein kinase A (PKA), also it inhibit the PFK-2 and the lowering of Fructose-2,6-bisphosphate (F26BP). And then gluconeogenesis was stimulated by reducing the PFK-1 activity which leads to the inhibition of glycolysis.

Related Questions

Navigate

• Browse (All)
• Browse U
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.