A. Explain why an organ transplant made between a donor of blood group AB and a

Question

A. Explain why an organ transplant made between a donor of blood group AB and a recipient of blood group O will always be rejected, even if it is perfectly HLA-matched and the recipient has been given immunosuppressant drugs. What is this type of rejection called?

B. Give another example of ABO incompatibility between donor and recipient that would lead to this type of rejection

C. What other antigen incompatibilities, other than those of blood group, are most likely to provoke this type of rejection?

D. Which pre-surgical laboratory test should be performed to prevent this type of rejection?

Explanation / Answer

A- The immune system of a person with O Blood group makes the antibody against the A and B group. SO when the organ from the AB blood group donor is transplanted to the O blood group recipient, the organ will be rejected by the immune system of the recipient.

B- Donar with blood group AB cannot donate the organ to the recipient with either blood group A or B.

C - Other type os antigen compatibility is HLA (human Leucocyte antigen). HLA markers are inherited from the parents. Each person has distinct HLA.

D - Serum crossmatch is performed to prevent the above-mentioned rejection. In cross match cells from the donor is incubated with the serum of the recipient. If the recipient has the antibody against the donor cells then donor cells will destroyed

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.