Understanding the stereochemistry of a chiral pharmaceutical drug allows medicin
ID: 801438 • Letter: U
Question
Understanding the stereochemistry of a chiral pharmaceutical drug allows medicinal chemists to synthesize and prepare the drug either in an enatiomerically ( or diastereomerically) enriched form, or as a racemic mixture of the various stereoisomers. What are the economics of manufacturing a drug either as a racemic mixture or in its biologically active form?
The high cost of drugs has forced some people to take drastic action such as leaving the US to buy drugs in other countries. Suggest alternative approaches to solving this problem.
Explanation / Answer
the nomenclature for describing stereochemistry and enantiomers, emphasizes the potential biological and pharmacologic differences between the 2 enantiomers of a drug, and highlights the clinical experience with single enantiomers of the selective serotonin reuptake inhibitors fluoxetine and citalopram. In some cases, both a mixture of enantiomers and a single-enantiomer formulation of a drug will be available simultaneously. In these cases, familiarity with stereochemistry and its pharmacologic implications will aid the practicing physician to provide optimal pharmacotherapy to his or her patients...
This difference in 3-dimensional structure prevents the inactive enantiomer from having a biological effect at this binding site. In some cases, the portion of a molecule containing the chiral center(s) may be in a region that does not play a role in the molecule's ability to interact with its target. In these instances, the individual enantiomers may display very similar or even equivalent pharmacology at their target site
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