Which of the following is a variation on the anticancer approach immunotoxins? a

Question

Which of the following is a variation on the anticancer approach immunotoxins? a. Is to genetically engineer the production of monoclonal antibodies that can bind to specific tumor antigens to neutralize them b. is to link monoclonal antibody that target a specific tumor antigen to an enzyme that catalyzes a nontoxic pro-drug conversion into an active cytotoxic drug within the tumor cell, a technique known as antibody-directed enzyme/pro-drug therapy (ADEPT) c. By linking monoclonal antibody to an enzyme that can catalyze the conversion of a nontoxic pro-drug into an active cytotoxic drug only a small amount of enzyme can generate much larger amounts of active cytotoxic drug in the immediate vicinity of tumor cells d. Is to link monoclonal antibodies against a specific tumor antigen to radioisotopes have been successfully used to kill certain tumors e. All the above approaches are a variation on the anticancer approach because they also kill neighboring tumor cells, because the released drug or radioactive emissions can affect cells adjacent to those that bind the antibody

Explanation / Answer

153. e

Monoclonal antibodies with the help of antibody drug conjugates specifically bind tumor associated target antigens and deliver a highly potent cytotoxic agent. This combination of monoclonal antibodies and a small molecule of chemotherapeutics.

154. a

Herd immunity confers resistance to the spread of a communicable disease within a population that occurs if a sufficiently high proportion of individual are immune to the disease especially through vaccination.

155. d

A better understanding of the immune system as well as the specific immune mechanism required for vaccination will be helpful in designing vaccines for many infectious diseases.

156. a

Live attenuated vaccines contain a living specifically weakened version of a virus or bacteria which provides lifelong immunity.

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