Tumor specific antigens are derived from______? (Please select all that apply. A

Question

Tumor specific antigens are derived from______? (Please select all that apply.

A. peptide antigens encoded by fused portions of recombined genes

B. peptide antigens containing point mutations.

C. proteins modified by abnormal post translational processes

D. Reactive embryonic genes

E. Viral proteins

F. Overexpression of normal genes

G. non contiguous peptides spliced together by peptide bonds in the proteasome

*** Also, if you could list any that are NOT included in the above list, it would be very helpful. TIA

Explanation / Answer

A. peptide antigens encoded by fused portions of recombined genes

B. peptide antigens containing point mutations.

E. Viral proteins

F. Overexpression of normal genes.

Mutant Protein produced in a tumor cell can act as a tumor antigen. Such abnormal proteins are produced due to mutation of the concerned gene. Mutations in either protooncogenes or tumor suppressor genes can lead to abnormal protein production are the cause of the tumor and thus such abnormal proteins are called tumor-specific antigens. Examples of tumor-specific antigens include ;

oncogenic viral antigens, cancer-testis antigens, Products of Other Mutated Genes, Oncofetal Antigens etc.

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