The following events occur during the action of dopamine as a neurotransmitter.

Question

The following events occur during the action of dopamine as a neurotransmitter. Race the events in the correct order, beginning with the newly synthesized dopamine in a neuron and ending with the terminator the nerve signal. The dopamine-containing vesicles travel to the cell membrane and fuse with it, releasing the dopamine into the synapse. Dopamine diffuses across the synapse. Dopamine binds to receptors on the postsynaptic neuron, generating a nerve impulse in the neuron. Dopamine is removed from the synapse and receptor site to end the nerve signal. Vesicles store dopamine in the presynaptic neuron. A nerve impulse travels to the presynaptic neuron.

Explanation / Answer

Dopamine is one of the very important neurotransmitters. Improper amount and functioning of dopamine has been found to be associated with Parkinson's disease. Dopamine is synthesized in the neurons and remains stored in the vesicles. When a nerve impulse reaches the neuron, it is released by the presynaptic neuron into the synaptic cleft usually by exocytosis. Dopamine then reaches the post-synaptic neuron and binds to specific receptors. This binding results in generation of impulse in the post synaptic neuron. Then, dopamine dissociates from the receptors and is again taken back by the presynaptic neuron, where it is either degraded or repackaged into vesicles.

So, the order of events is as follows:

1. Vesicles store dopamine in the presynaptic neuron.

2. A nerve impulse travels to the presynaptic neuron.

3.The dopamine containining vesicles travel to the cell membrane and fuse with it, releasing dopamine into the synapse.

4. Dopamine diffuses across the synapse.

5. Dopamine binds to the receptor on the post-synaptic neuron, generating a nerve impulse in the neuron.

6. Dopamine is removed from the nerve synapse and receptor site to end the nerve signal.

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