Bradykinin is a nonapeptide that is responsible for the severe pain most people

Question

Bradykinin is a nonapeptide that is responsible for the severe pain most people feel after being stung by a wasp. Amino acid analysis of bradykinin gave the following composition of amino acids:

Pro3, Phe2, Arg2, Gly, Ser

Edman degradation indicated that the N-terminal amino acid was Arg. Carboxypeptidase treatment gave Arg as the first-appearing amino acid followed closely by Phe. Partial hydrolysis of bradykinin gave five fragments:

l. Pro2, Arg; N-terminal AA: Arg

2. Arg, Pro, Phe; N-terminal AA: Pro

3. Gly, Pro; N-terminal AA: Pro

4. Ser, Phe, Gly; N-terminal AA: Gly

5. Ser, Phe; N-terminal AA: Phe

Note: Commas separating amino acids in a list do not imply an order or specif

Explanation / Answer

Part 1: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Part 2: Proline and Phenalalanine prevent alpha-helix chain formation due to size of ring substituents

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