9. Replacement of an A by a T in a region of the human gene for the B chain of h
ID: 78558 • Letter: 9
Question
9. Replacement of an A by a T in a region of the human gene for the B chain of hemoglobin is associated with sickle-cell anemia:
Normal: 5-ATGGTGCACCTGACTCCTGAGGAGAAGTCT-3
Sickle cell: 5-ATGGTGCACCTGACTCCTGTGGAGAAGTCT-3
(a) What is the nucleotide sequence of the normal and sickle-cell hemoglobin mRNA?
(b) What is the amino acid sequence in this part of the Bpolypeptide chain, and what is the amino acid replacement that results in sickle-cell hemoglobin?
(c) Why might this amino acid substitution make a difference in protein structure?
Explanation / Answer
Normal chain= AUGGUGCACCUGACUCCUGAGGAGAAGUCU
Sickle cell anemia chain=AUGGUGCACCUGACUCCUGUGGAGAAGUCU
Normal chain= MVHLTPEKS
Sickle cell anemia chain=MVHLTPEKS
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