1)Suppose you were studying an enzyme that hydrolyzes the C-terminal amino acid

Question

1)Suppose you were studying an enzyme that hydrolyzes the C-terminal amino acid off a small peptide hormone.  Your studies suggest that the active site has two carboxylic acid groups that participate in the reaction.   The figure below shows a suggested active site, with the substrate in the active site (the peptide) and amino acid side chains (all labelled as "A")

1a)Using the active site shown, suggest amino acids in the enzyme for A1--->A6 (A6 could represent several amino acids)

1b) WRITE A CHEMICAL ENZYME MECHANSIM FOR THIS REACTION, SHOWING HOW THE ENZYME PARTCIPATES IN THE REACTION

Suppose you were studying an enzyme that hydrolyzes the C-terminal amino acid off a small peptide hormone. Your studies suggest that the active site has two carboxylic acid groups that participate in the reaction. The figure below shows a suggested active site, with the substrate in the active site (the peptide) and amino acid side chains (all labelled as "A") Using the active site shown, suggest amino acids in the enzyme for A1--->A6 (A6 could represent several amino acids) WRITE A CHEMICAL ENZYME MECHANSIM FOR THIS REACTION, SHOWING HOW THE ENZYME PARTCIPATES IN THE REACTION

Explanation / Answer

www2.fiu.edu/~bch3033/probsolns/solutionsch06.pdf%u200E

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