There had been a long-standing controversy between two different hypotheses abou

Question

There had been a long-standing controversy between two different hypotheses about the trafficking of proteins through the Golgi that was resolved in a set of experiments that you studied this semester.

A)(1pt) What were the two hypotheses?

B)(1pt) Briefly describe the critical experiments that solved this controversy making clear which hypothesis was confirmed.

C)(1pt) What experimental evidence would have confirmed the other hypothesis?

D) (1 pt) Given that the experiments you studied were done in unicellular yeast, which hypothesis would you favor for mammalian cells? (note: the genes involved in transport and modification are so strongly conserved between yeast and mammals that the mammalian genes work in yeast)

Explanation / Answer

there areTwo models discussed protein trafficking through Golgi.
the first is - The cisternal maturation model of the protein.where a new cis cisterna is developed it crosses the Golgi stack, changes in takes place simultaneously while its maturing, then trans enzymes through vesicles that move from cisternae formed later to cisternae formed earlier.
the second one is - The vesicular transport model, in which each cisterna beholds in one place with more or less unchangeable enzymes, and the proteins makes way through the stack through vesicles that move from earlier formed cisternae to lately formed cisternae

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