You are trying to find the cholesterol-deficiency mutation in Holstein calves on

Question

You are trying to find the cholesterol-deficiency mutation in Holstein calves on the chromosome to the left and find a significant association of disease with SNP a, which is a G nucleotide, whereas SNP A is an A nucleotide. (i) The statistical test for significance tests the hypothesis that two things are associated by random chance. To be significant, the p value must be less than or equal to 0.05.The p value for the association of SNP a with the disease is 1 times 10^-9. Is the probability that SNP a and the disease are associated by random chance high or low? __________ (ii) The p value for the association of SNP e with the disease is 1 times 10^-1. Is the probability that SNP e and the disease are associated by random chance high or low? __________ (iii) Is it more likely that SNP c or that SNP b is also associated with the disease? __________ Why? Use the terms crossing-over or recombination.

Explanation / Answer

Its a genetic disorder in which crossing over or recombination that is trransfer of gene between to sister chromosome occured during cell division.

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