I am doing some multiple choice questions and have difficulties in the following

Question

I am doing some multiple choice questions and have difficulties in the following questions.

1. In which of the following scenarios would gene expression be the lowest?

A. The GpG island upstream of a gene is unmethylated

B. Injecting antisense RNA corresponding to the mRNA of a gene

C. Deletion of a sequence upstream of a gene known to be a silencer

D. Injecting double-stranded RNA corresponding to the mRNA of a gene

E. activation of histone acetyltransferase

2. Which statement about rRNA molecule is true?

A. The presence of modified nucleotides predominantly determines structure

B. Each molecule folds into a common 3D structure for function

C. they undergo extensive processing to add a cap and poly A tail

D. They function as protein: RNA complexes

E. They are the enzymatic components of splicing complexes

3. Which of the following is least likely to happen on a day to day basis?

A. doule strand break B. hydroxylation C. deamination D. pyrimidine dimers E. Tautomerization

4. which of the following processing events occur in the generation of mature tRNA molecules?

A. polyadenylation at the 3' end

B. addition of a 5' cap

C. convalent modification of bases

D. intron removal to create an ORF

E. cleavage of mutiple function molecule from a larger precursor

5. translation of the mRNA encoding the collagen polypeptide takes place on the rough endoplasmic reticulum. Knowing where collagen polypeptide must ultimately end up, you would predict which of the following features for the first 20 amino acids of the just-translated collagen polypeptide?

A. the sequence will form an amphipathic helix

B. the sequence will contain many hydrophobic residues

C. the sequence will contain many arginine and lysine residues

D. the sequence will contain leucine residues with requisite spacing

E. the sequence will contain saccharide residues in place of amino acid

6. Which statement about epigenetic reprogramming is true?

A. somatic cells undergo extensive demethylation postnally (newborn period)

B. somatic cells erase genomic imprints to reestablish totipotency

C. germ cells of females only erase and reestablish genomic imprints in the embryonic period

D. somatic cells do not erase inherited genomic imprints

E. germ cells undergo extensive demethylation beginning at puberty

7. There are 20 primary amino acids specified by the genetic code. Which step in the translation process requires a separate and specific enzyme for each amino acid?

A. joining an individual amino acid to its specific tRNA   

B. delivering aminoacyl-tRNA to the ribosome

C. initiating translation

D. peptide bond formation

E. translocation of ribosome to the next codon along the mRNA   

Explanation / Answer

1. In which of the following scenarios would gene expression be the lowest?

Ans. B. Injecting antisense RNA corresponding to the mRNA of a gene. The antisense RNA will bind to the corresponding mRNA which will not allow the mRNA to undergo translation.This action will repress the function of mRNA this will lower the gene expression.

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