Ethanol (found in alcoholic beverages) is metabolized in the liver to ethanal by

Question

Ethanol (found in alcoholic beverages) is metabolized in the liver to ethanal by the enzyme alcohol dehydrogenase. Since the alcohol is oxidized, something has to be reduced. The substance that gets reduced is the oxidized form of nicotinamide adenine dinucleotide (abbreviated NAD+). The proposed mechanism for this redox reaction is given below. For the reduction half reaction NAD+ NADH. Based on the mechanism given above, indicate whether or not the given deuterated alcohol will produce NADD upon oxidation (NADD is the deuterated analog of NADH). Draw the indicated species given below. Use the X window to type in the R.

Explanation / Answer

If you draw out a, b, and c, it will help you figure out which will and will not produce NADD. a)The Deuterium is attached to the Oxygen which is grabbed by the Base so that will not produce NADD. b)The Deuterium is on the Carbon attached to the other Carbon and not the Oxygen. These are left unaffected by the reaction; therefore, will not produce NADD. c)The Deuterium is on the Carbon attached to the Oxygen. Show by the figure, this will produce NADD. I hope I helped you understand!

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