Recent studies have shown that a gene encoding an RNA with an intron can yield [

Question

Recent studies have shown that a gene encoding an RNA with an intron can yield [____], depending upon where the intron is spliced and what parts of the intron are included in the mature transcript. Related to this, other studies have shown that certain chromatin remodeling factors can reduce the activating [____] of the RNA polymerase II, causing it to [____] in RNA synthesis. In a new RNA with a weak [____] within an intron that competes with a normal, strong 3-splice site downstream at the intron/exon junction, the normal, fast elongation of the polymerase would not allow exposure of the weak splice site. But if the polymerase [____] before reaching the strong splice site, an alternative exon may be created because of use of the weak 3-splice site.

Please pick one.

(1) mutant proteins; TFIIH; accelerate; 5-splice site; stops

(2) cryptic splice sites; phosphorylation; decrease; termination signal; accelerates

(3) new splice sites; acetylation; increase; 3-splice site; arrests

(4) alternate products; phosphorylation; slow; 3-splice site; stalls

(5) longer mRNAs; assembly; accelerate; transcription arrest; dissociates

Explanation / Answer

Ans: (1) mutant proteins; TFIIH; accelerate; 5-splice site; stops

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