What are the genes involved in risk assessment, early detection and treatment of

Question

What are the genes involved in risk assessment, early detection and treatment of colon cancer? What kind of mutation occurs in FAP? Describe the ethical issues involved in genetic testing. Name the drugs used for the treatment of colon cancer and what is their mechanism of action? Can risk assessment be used for both familial and non familial cases of cancer? What are the tests used for early detection of non familial colon cancer? Is cancer age dependent? Give reasons What are the body's defenses against cancer? Can cancer be detected before they are metastatic? What parts of the body tend to develop metastatic cancer?

Explanation / Answer

1. Oncogenes such as c-myc and and ras are involved.

2. FAP (Familial adenomatous polyposis) is caused by changes (mutations) in the APC gene inherited from parents.

3. Some genetic tests are not able to detect all possible gene mutations that can cause a particular condition and have limited predictive value. The test subsequently requires difficult decisions without providing full information.

4. 5-Fluorouracil (5-FU), Irinotecan, Capecitabine.  The principal mechanism of action of fluoropyrimidines is the the inhibition of thymidylate synthase.

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