Recent research has pointed to a new role for [___] in the genetic changes leadi
ID: 74788 • Letter: R
Question
Recent research has pointed to a new role for [___] in the genetic changes leading to the induction of cancer. The [___] concentrated in gene promoters are vulnerable to de novo [___], and when promoters in genes for [___] enzymes are [___] by this process, the cell experiences genetic instability, with elevated uncorrected mutations.
(1) environmental carcinogens, methyl cytosine bases, chromatin silencing, DNA repair, stimulated
(2) spontaneous methyl cytosine deamination, CpG islands, chromatin methylation, methylation, inhibited
(3) epigenetics, CpG islands, hypermethylation, DNA repair, silenced
(4) enhanced UV absorption, methyl cytosine bases, hypomethylation, regulatory kinases, unregulated
(5) enhanced carcinogen binding to CpG residues, methylation, chromatin silencing, methylating, blocked
Explanation / Answer
Recent research has pointed to a new role for environmental carcinogens in the genetic changes leading to the induction of cancer. The methyl cytosine bases concentrated in gene promoters are vulnerable to de novo chromatin silencing, and when promoters in genes for DNA repair enzymes are stimulated by this process, the cell experiences genetic instability, with elevated uncorrected mutations.
The environmental carcinogens are responsible for causing several types of cancers. The carcinogens cause accumulation of methyl cytosine bases that lead to gene silencing and result in denovo methylation. The DNA repair enzymes stimulated in response to gene silencing may not repair the genetic errors correctly and hence may result in unwanted mutations and cause genetic instability. Hence, option (1) is correct.
.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.