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Below is an example of a Glucose Tolerance Test (GTT) At the start of the GTT, a

ID: 74474 • Letter: B

Question

Below is an example of a Glucose Tolerance Test (GTT)

At the start of the GTT, a patient drinks a solution of glucose. Blood is then drawn every half hour or so, and blood/plasma glucose concentration is measured at each time point. In the normal subject (blue curve), glucose concentration steadily increases during the first half hour. What is happening here?

a. Liver receives a hormonal signal to increase the production and release of glucose via gluconeogenesis.

b. The glucose solution is digested, absorbed in the small intestine, passed into the portal circulation to the liver, and is subsequently released into the blood.

c. There is an increased mobilization of glycogen stores and glucose release from the liver.

d. The glucose solution is digested then directly utilized by many organs in the body, leading to an increase in glucose in the blood.

e. A and C

250 O 200 9 Diabetic subject g 150 C 100 Normal subject 50 2 Time after oral glucose (hr) Fasting plasma glucose concentration 6

Explanation / Answer

e. A and C

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