Irregular loops of secondary structure tend to be located on the outside of fold

Question

Irregular loops of secondary structure tend to be located on the outside of folded proteins because:

A. Their side chains are to bulky to fit inside the protein.
B. Peptide bonds in loop structures are free to form hydrogen bonds with water.
C. The side chains in loop structures are free to form hydrogen bonds with water.
D. These regions of the peptide tend to contain mostly polar side chains.
E. Alpha helices and Beta sheets are located toward the center of the protein leaving no room for the loops.

Explanation / Answer

The answer is B

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