Problem 1 Review the attached oxygen-hemoglobin dissociation curve . a) Draw an

Question

Problem 1 Review the attached oxygen-hemoglobin dissociation curve.

a) Draw an equation that shows the loading and unloading of oxygen.

b) From the curve, what is the % oxygen saturation of hemoglobin in venous blood.

c) What volume and percent of hemoglobin bound oxygen is unloaded to the tissues? Mark this point on your curve.

d) Draw a 2nd curve on this figure that shows a dissociation curve in tissues experiencing acidosis.

e) Explain in your own words what your second curve shows. How does declining blood pH affect the Hb-02 bond?

O2 bond?

Explanation / Answer

For oxygen-hemoglobin dissociation curve,sigmoidal curve is formed.

the reverisble reaction M+LML, where M is free macromolecule, L is free ligand, and ML is macromolecule-ligand complex (which is held together by intermolecular forces, not covalent forces):

Kd=[M]eq[L]eq/[ML]eq

Factors That Shift the O2 Dissociation Curve:-(review oxygen hemoglobin binding curve)

pH

Decreased pH - right shift (decreased affinity)

- enhances the unloading of O2 at the tissue cells

- caused by increased PCO2 as CO2 moves into the blood from the cells

Increased pH - left shift (increased affinity)

- enhances the loading of O2 in the lungs

- caused by decreased PCO2 as CO2 moves from the blood into the alveoli

Temperature

Increased temperature - right shift (decreased affinity)

- enhances the unloading of O2 in actively metabolizing tissues (muscles during exercise)

Decreased temperature - left shift (increased affinity)

- Enhances loading of O2 in the lungs

- O2 is not readily released to peripheral tissues (blue lips, ears, fingers)

Overall:

Left Shift (Increased Affinity)

- Enhances loading of O2 in the lungs

- Decreases unloading of O2 to the tissue cells

- The PaO2 reduction to unload O2 at the tissues is greater

Right Shift (Decreased Affinity)

- Enhances unloading of O2 to the tissue cells

- The PaO2 reduction to unload O2 at the tissues is less

- Decreases loading of O2 in the lungs

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