There are three main types of coat protein associated with transport vesicles. W

Question

There are three main types of coat protein associated with transport vesicles. What is the general purpose of these coat proteins? and where would each of the three types be found in the exocytotic and endocytic pathways of the cell

Describe the mechanisms by which a transport vesicle is able to find and fuse with its target membrane. Be sure to include all relevent proteins and processes involved in the recognition, docking and fusion of membranes

Glycosylation performs many important functions in the cell, from ensuring the proper folding of proteins to cell-cell recognition. What are M6P groups, where are they added, and what is their purpose in exo/endocytotic cycling? How is their proper function reliant on organellar pH?

Explanation / Answer

- The three types of coat proteins are clathrin, COPI and COPII.

Vesicles trafficking between the Golgi and plasma membrane constitute the clathrin coats.

COPI coated vesicles are responsible for retrograde transport from the Golgi to the ER, while COPII coated vesicles are responsible for anterograde transport from the ER to the Golgi.

Transport vesicles can move or deliver molecules between the organelles in the cell. From endoplasmic reticulum to Golgi transport of proteins. These vesicles are made up of lipid membranes and pinch off from the cell wall only. So, the constitutions are same which facilitates in the fusion of the vesicle with the target memrane.

Vesicle coat proteins are helpful in capturing the cargo materials and also in recognition.

SNARE's, the surface markers are responsible for the docking of the vesicle. Next, the fusion of vesicle takes place with the utilization of ATP energy.

AFter the transport function of these vesicles they ae degeraded by tagging with ubiquitin.

Mannose-6-phosphate plays role in protein targeting. They are sinalling molecules for the lysosomal enzymes in the cell.It binds to specific receptor on trans Golgi. The protein associated with mannose-6-phosphate will be transported to lysosome. Low pH around 5 is needed for the transport mechanism.

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