Osteopontin is an acidic 70-kDa glycoprotein that is cleaved by proteases to yie

Question

Osteopontin is an acidic 70-kDa glycoprotein that is cleaved by proteases to yield 45-kDa and 25-kDa mature and functional fragments. Osteopontin is synthesized first as a single polypeptide chain but oligosaccharides (sugar groups) are then attached to the glycosylation sites (side chain of serine, threonine, or asparagine). The coding sequence of the human osteopontin mRNA is exactly 900 nucleotides in length. The molecular weight of the non-glycosylated human osteopontin protein is approximately ____ kDa (1 kDa = 1,000).

A. 25

B. 33

C. 45

D. 70

E. 90

Explanation / Answer

The functional osteopontin is made up off 300 amino acid and its molecular weight is approximately 33 kDa

so option B is answer

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