1, The following type of mutation is most likely to result in an error protein s

Question

1, The following type of mutation is most likely to result in an error protein synthesis:

A. Replacement of a G for I at the 5’ end of the anticodon

B. Replacement of a C for A at the 3’ end of the anticodon

C. Replacement of a U for a C at the 3’ end of the codon

D. A and C

E. None of the above

2. A protein recovered from a cell culture after introduction of a pulse of 15N-labeled amino acids will have:

A. Most of the 15N-label in the amino acids nearest the N-terminus

B. Most of the 15N-label in the amino acids nearest the C-terminus

C. The label equally distributed throughout the protein sequence

D. No label incorporated into protein

E. None of the above

3. Which of the following statements best describes the composition of the ribosome?

A. It is composed mostly of protein

B. It is composed mostly of RNA

C. It’s transpetidase activity is RNA catalyzed

D. It’s transpeptidase activity is protein catalyzed

E. Both B and C

4. Choose the correct answer to complete the statement: In the assembly of the ribosome

A. The ribosomal proteins first associate to from a scaffold for the folding of ribosomal RNA.

B. The ribosomal RNA first folds and forms a scaffold for the binding of ribosomal proteins.

C. The ribosomal RNA and proteins assemble in a random order.

D. The ribosomal proteins interact only indirectly with ribosomal RNA.

E. None of the above

Explanation / Answer

2). C. The label equally distributed throughout the protein sequence

3). E. Both B and C

The ribosomes are composed of one or more ribosomal RNA molecules. The transpeptidase activity of ribosomes is not catalysed by ribosomal proteins but it is RNA catalysed (rRNA).

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