You have developed a mouse strain called XYZ that models the autiimmune disease
ID: 72730 • Letter: Y
Question
You have developed a mouse strain called XYZ that models the autiimmune disease pemphigus, where autoantibodies are made that destroy the tight junctions in the dermis, resulting in blisters and exfoliation. This leads towards the life-threatening disease. As mice develop the disease over their first 24 weeks of age, the severity can be scored on a scale of zero (least severe) to five (most severe). Assume that you bred these mice to TRL7 qne TLR9 knockouts, creating both since and double knockouts.
Below is the question I need help with:
1. Assume you discover the effect of TLR9 in this experiment requires its expression in T cells BUT not B cells. Briefly discuss several important pieces of information you would like to learn about this phenomenon.
Disease severity score TLR7 KO TLR9 KO TLR7/9 Age (weeks) XYZ KO XYZ ny XYZ XYZ 12 18 24 1Explanation / Answer
2)
Here, the TLR9 gene KO mice’s express more amounts of autoantibodies, therefore it has more severity and kills the mice’s from the age of 6 weeks. Here, the gene product from the TLR9 gene binds with T-cell MHC and form a cross linking with B-cells and activate them to produce autoantibodies. These autoantibodies trigger the events that lead to occurrence of disease.
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