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Shown below are two homologous lengths of the a and b chains of human hemoglobin

ID: 72671 • Letter: S

Question

Shown below are two homologous lengths of the a and b chains of human hemoglobin. Consult the genetic code dictionary and determine how many amino acid substitutions may have occurred as a result of a single-nucleotide substitution. For any that cannot occur as the result of a single change, determine the minimal mutational distance.

1. The change from Ala - Gly requires five changes.

2. The change from Pro - Lys requires two changes.

3. The change from Val - Leu requires two changes.

5. The change from Pro - Lys requires three changes.

Ala Val Ala His Val Asp Asp Met Pro Glu Leu Ala His Leu Asp Asn Leu Lys

Explanation / Answer

Diverse amino acids are coded by distinctive triples of nucleotides in DNA of the genes, this code is currently known. Most mutation includes substitutions of single nucleotides some place in DNA chain coding for a given protein. Subsequently one can figure the base number of single mutations expected to change the cytochrome C of one life form into that of another.

GCC3'

GUA

GCC3'

CAU

GUA

AUG

CCU

Ala

Val

Ala

His

Val

Asp

Asp

Met

Pro

Glu

Leu

Ala

His

Leu

Asp

Asn

Leu

Lys

CAA

TTA

GCC3'

CAC

UUA

AAC

UUA

AAG

GCC3'

GUA

GCC3'

CAU

GUA

AUG

CCU

Ala

Val

Ala

His

Val

Asp

Asp

Met

Pro

Glu

Leu

Ala

His

Leu

Asp

Asn

Leu

Lys

CAA

TTA

GCC3'

CAC

UUA

AAC

UUA

AAG

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